Updated May 2026 · BLS OEWS 2025
Physician Assistant Salary in Greenville, SC
Healthcare · SOC 29-1071 · COL Index 90.1
Physician Assistants in Greenville, SC earn a median salary of $123,310 as of 2025, with a 10th-to-90th percentile range of $51,850 to $164,990. The mean is $116,630 across approximately 440 workers. Adjusted for Greenville, SC's cost-of-living index of 90.1, the median equates to $136,859 of purchasing power in an average-cost U.S. metro.
Physician Assistant in Greenville, SC pays below the national median: $123,310 locally versus $138,339. The discount usually reflects either lower cost-of-living, smaller local industry concentration, or weaker labor demand.
Cost-of-living in Greenville, SC runs below the national baseline (index 90.1). The cost-adjusted purchasing power of $123,310 works out to roughly $136,859 in national-baseline dollars — often higher real income than in high-cost coastal cities at the same gross wage. Wage distribution at the 25th, 50th, 75th, and 90th percentiles: $80,434, $123,310, $144,150, $164,990. 440 Physician Assistant workers are documented in Greenville, SC per the BLS OEWS survey. The percentile spread is the most useful framing — entry-level pay clusters near p25, mid-career near p50, senior-level near p75-p90.
Salary Distribution
Percentile Breakdown
| Percentile | Salary | COL-Adjusted |
|---|---|---|
| 10th Percentile (Entry Level) | $51,850 | $57,547 |
| 25th Percentile | $80,434 | $89,272 |
| 50th Percentile (Median) | $123,310 | $136,859 |
| 75th Percentile | $144,150 | $159,989 |
| 90th Percentile (Top Earners) | $164,990 | $183,119 |
What These Numbers Tell You
The spread between the 10th and 90th percentile for Physician Assistants in Greenville, SC is unusually wide — top earners take home roughly 3.2× what the bottom decile earns. That signals a long career ladder: substantial pay gains accrue with seniority, specialization, and movement to larger employers. Workers entering this role should expect to start near the 25th percentile and target the median by year three to five.
Greenville, SC's cost-of-living index of 90.1 runs below the U.S. average, so a $123,310 salary here has the equivalent purchasing power of about $136,859 in an average-cost metro. Lower nominal pay in markets like this often translates to comparable or better real income than higher headline numbers in coastal hubs.
Greenville, SC ranks #62 of 70 BLS-tracked metros for Physician Assistant pay — in the lower half nationally (89th percentile). Lower nominal pay here is often offset by a lower cost of living; check the COL-adjusted figure on this page for an apples-to-apples comparison.
How to Use This in Negotiation
The classic negotiation move is to anchor your ask on the 75th percentile of the BLS band — $144,150 for Physician Assistants in Greenville, SC — when you have meaningful experience, then bring evidence (years on the job, scope of past work, relevant certifications, comparable offers) to justify why you sit at that point in the distribution. Anchoring on the median when you have 5+ years of experience leaves money on the table; anchoring on the 90th percentile ($164,990) without strong evidence undercuts credibility.
For new entrants, the 25th-to-50th percentile band ($80,434–$123,310) is the realistic target. For mid-career workers, the median-to-75th band ($123,310–$144,150) is the right anchor. Senior specialists and managers should be benchmarking against the 75th-to-90th band ($144,150–$164,990).
For specific scripts and a full negotiation framework, see the data-driven salary negotiation guide. To benchmark your current pay, the salary percentile calculator places any number into the BLS distribution for this role and metro.
How This Salary Is Calculated
Wage figures come from the U.S. Bureau of Labor Statistics' Occupational Employment and Wage Statistics (OEWS) program — a federal survey of about 1.2 million U.S. establishments, published once per year by Metropolitan Statistical Area (MSA) and Standard Occupational Classification (SOC) code. The Greenville, SC percentile bands above (10th, 25th, 50th, 75th, 90th) and the mean are pulled directly from the BLS data file for SOC code 29-1071 in this MSA. The COL-adjusted figure rebases salary to a U.S. national average COL of 100, using a composite index derived from public housing, food, and transportation data. Read the full methodology for details.
Frequently Asked Questions
What is the average Physician Assistant salary in Greenville, SC?
Physician Assistants in Greenville, SC earn a median salary of $123,310 as of 2025, based on Bureau of Labor Statistics OEWS data. The mean (employment-weighted average) is $116,630 across roughly 440 workers in this metro.
What is the salary range for Physician Assistants in Greenville, SC?
Pay ranges from $51,850 at the 10th percentile to $164,990 at the 90th percentile — a $113,140 spread. The 25th-to-75th percentile band ($80,434 to $144,150) is the typical anchor for salary negotiation.
Is $123,310 a good Physician Assistant salary in Greenville, SC?
$123,310 is the BLS median — half of Physician Assistants in Greenville, SC earn more, half earn less. Whether it is "good" depends on your experience: new entrants typically land near the 25th percentile ($80,434), mid-career workers near the median, and senior specialists near or above the 75th percentile ($144,150). Cost-of-living-adjusted to a national average baseline, the median equates to $136,859.
How does Physician Assistant pay in Greenville, SC compare to other metros?
Greenville, SC ranks #62 of 70 BLS-tracked metros for Physician Assistant median pay. Nominal pay is in the lower half of U.S. metros, though the cost of living usually offsets at least part of that gap.
Where does this Physician Assistant salary data come from?
Every wage figure comes from the U.S. Bureau of Labor Statistics' Occupational Employment and Wage Statistics (OEWS) program at bls.gov/oes — public domain federal data covering 1.2 million U.S. employers. The same data feeds the U.S. Department of Labor's prevailing wage system used for H-1B and federal contracting wage determinations.
Source: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics, Greenville, SC MSA, SOC 29-1071, 2025 release. Public domain. See bls.gov/oes. Cite as: "SalaryTruth, BLS OEWS 2025."
Last refreshed 2026-05-21 · 440 Physician Assistants tracked in Greenville, SC.